San Mateo County health officials have announced the nation’s first known case of a severe form of mpox that has fueled an outbreak of the disease across Eastern and Central Africa.

There is no evidence that the strain is spreading in California or the U.S., and the risk of contracting Clade I mpox in the U.S. remains low.

San Mateo County health officials said on Saturday they have reported the first known case of clade I mpox in California and the United States.