Research led by Duke University, Durham, has discovered a situation-dependent traffic jam in mRNA translation caused by RNA hairpins leading to higher translation of upstream start codons (uAUGs).

During translation, multiple ribosomes travel along the nucleic acid chain to build polypeptides that become functional proteins. Occasionally, these molecular decoders pause on the mRNA, either ...

Researchers explored how the incorporation of N1-methylpseudouridine (1-methylΨ) into mRNAs affects ribosomal frameshifting and the overall fidelity of mRNA translation.

Only later are they parlayed into a medical technology that helps humanity. The mRNA modification discovery could be considered to be on a relatively fast track from basic science to application.

When the team tested the multi-tailed mRNAs in human cells, they sustained mRNA translation much longer than both natural mRNA and mocRNA, producing up to 20 times more proteins per dose over time.

Aging selectively impairs the production of crucial DNA- and RNA-binding proteins, which contributes to hallmarks of aging in the brains of killifish, according to a new study.

The research team demonstrated that RELISR enables temporal and spatial regulation of protein activity and mRNA translation in various cell types, including cultured neurons and mouse liver tissue.

The mRNA research conducted by Katalin Karikó and Drew Weissman exemplifies the unpredictable value of basic scientific research ...

Harnessing the power of mRNA, a naturally occurring molecule that tells the body how to make a protein, experts in the field ...

The trick for specific CCND2 translation in heart muscle cells is that the L7Ae mRNA has been engineered to have recognition elements for the cardiomyocyte-specific microRNAs miR-1 and miR-208. Those ...

image: New mRNA produces 200 times more protein: Hope for treatment of cancer and protein disorders view more Credit: Mizuki Tada Imagine a breakthrough in cancer treatment where only malignant ...