The human genome contains about 23,000 genes, but only a fraction of those genes are turned on inside a cell at any given time. The complex network of regulatory elements that controls gene expression ...

When the Nanog gene (green region) is inactive, one of the three enhancer regions is spatially far away. When active, the same enhancer region makes close contact, interacting with the other enhancers ...

Enhancers, which are thought to turn genes on by coming into physical contact with gene promoter regions through transiently forming a complex, were discovered about 45 years ago. More recently, in ...

DNA transcription is the vital first step needed for switching on our genes. For a gene to be switched on, it must be acted upon by an enzyme called RNA polymerase. This is a molecular machine which ...

Over the course of three months, Professor Michael Levine’s lab at the Department of Molecular Biology and the Lewis-Sigler Institute for Integrative Genomics have published two papers elucidating the ...

New Study Reveals How the C/G Fusion Hijacks DNA Methylation and Chromatin Architecture to Drive Aggressive AMKL Pediatric ...

A new study shows, for the first time, how the human genome folds and moves in 3D over time to control when genes turn on and ...

The non-coding genome, once dismissed as "junk DNA", is now recognized as a fundamental regulator of gene expression and a key player in understanding complex diseases. Following the landmark ...

Multiple myeloma (MM) affects over 5,500 people annually in the UK, with a 5-year survival rate below 50% in advanced stages. Resistance to therapies is driven by transcriptional addiction, where ...

Our bodies follow a natural 24-hour cycle known as the circadian rhythm that influences everything from sleep to metabolism. While scientists have long known that certain core circadian clock genes ...