Telomerase is an important drug target for cancer. It is expressed in most tumours from virtually all types of cancers and is required for long-term maintenance of telomeres, which in turn is crucial ...

Study shows how telomerase can run amok, deleteriously capping damaged DNA, were it not for a first responder to DNA damage. The natural ends of chromosomes appear alarmingly like broken DNA, much as ...

The aging process - it's undignified, unwanted, and many would say unnecessary. After all, the cells in your body are constantly replacing themselves – why can't they do it without causing progressive ...

Scientists have for the first time mapped telomerase, an enzyme which has a kind of rejuvenating effect on normal cell aging. The findings are a step forward in the fight against cancer. In ...

Researchers at Arizona State University’s (ASU) School of Molecular Sciences and the Biodesign Institute’s Center for the Mechanism of Evolution have discovered an unprecedented pathway producing ...

Premature aging can be reversed by reactivating an enzyme that protects the tips of chromosomes, a study in mice suggests. Mice engineered to lack the enzyme, called telomerase, become prematurely ...

Sometimes stories that start with pond scum can have good endings. In the case of the single-celled organism called Tetrahymena thermophila, important bits of DNA at the ends of its chromosomes led to ...

Role of Telomeres and Telomerase in the Pathogenesis of Human Cancer. If you have the appropriate software installed, you can download article citation data to the citation manager of your choice.

Telomeres – which are the DNA repeats that form the tips of chromosomes and are produced by the telomerase enzyme – play a crucial, and curious, role in the life of the cell. While chromosomes are ...

A study by Children's Medical Research Institute (CMRI) researchers reveals a new group of proteins that guide the powerful enzyme telomerase, opening potential doors to novel treatments for cancer, ...