α-Synuclein (α-Syn) is a presynaptic protein primarily associated with Parkinson’s disease and other neurodegenerative diseases. The cholesterol content in SV membranes regulates α-Syn binding to ...
A vesicle, only a few nanometers in size and filled with neurotransmitters, approaches a cell membrane, fuses with it, and ...
Jennifer Morgan (Marine Biological Laboratory or MBL) and Dragomir Milovanovic (German Center for Neurodegenerative Diseases (DZNE) have formed a large collaboration at the MBL to understand how ...
Researchers at Johns Hopkins Medicine say they unexpectedly found new information about a protein's special role in getting brain cells to communicate at the right time and place in experiments with ...
How do we think, feel, remember, or move? These processes involve synaptic transmission, in which chemical signals are transmitted between nerve cells using molecular containers called vesicles. Now, ...
Zacharie Taoufiq, Momchil Ninov, Alejandro Villar-Briones, Han-Ying Wang, Toshio Sasaki, Michael C. Roy, Francois Beauchain, Yasunori Mori, Tomofumi Yoshida, Shigeo Takamori, Reinhard Jahn, Tomoyuki ...
Proceedings of the National Academy of Sciences of the United States of America, Vol. 117, No. 25 (June 23, 2020), pp. 14493-14502 (10 pages) A high rate of synaptic vesicle (SV) release is required ...
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