Researchers identify GRIN2A as a rare single-gene cause of early psychiatric disorders, with symptoms often beginning in ...

N-methyl D-aspartate (NMDA) receptors are ligand-gated cation channels activated by glutamate, an excitatory neurotransmitter. These receptors are located mostly at excitatory synapses and, thereby, ...

Research links variations in the gene GRIN2A to a higher risk of developing schizophrenia and other forms of mental illness.

Figure 1: Co-agonist stimulation induces dynamin-dependent NMDA receptor internalization. Figure 2: Glycine site stimulation initiates a progressive decline in NMDA receptor-mediated currents. Figure ...

The difference between mental health and mental illness can turn on changes in brain cells and their connections that are almost incomprehensibly tiny, at least in physical terms. This irony is ...

Addressing major unmet needs in mental health with pharmacology rooted in emerging and clinically validated neuropsychiatric biology * Lead progra ...

Figure 1: CP-101,606 and ifenprodil inhibit NMDA receptors in a subunit selective and noncompetitive fashion. Figure 2: Phenylethanolamines enhance proton inhibition of the NMDA receptor. These ...

Mental illnesses are thought to directly impact about one in every seven people worldwide, according to the World Health ...

Drugs that act on NMDA (N-methyl-D-aspartate) receptors, which are essential for learning, memory and moment-by-moment consciousness, are key for treating neuropsychiatric disorders. These drugs were ...

In February 2025, Ryan Alto, a 48-year-old from California, developed what seemed like a routine flu. He had a headache, body aches, and general fatigue, but within hours of driving himself to the ...

One of several types of ligand-gated ion channel, the N-methyl-D-aspartate (NMDA) receptor transmits excitatory stimuli in the brain. When calcium flows through this channel, neural plasticity happens ...