Serum urate-associated genetic variants strongly contribute to gout risk regardless of diuretic use, according to research results published in Journal of Rheumatology. Based on study data, the ...

Single-nucleotide polymorphisms associated with serum urate can strongly influence gout susceptibility in the presence of other risk factors, according to investigators. Serum urate (SU)-associated ...

Kidney stones affect nearly 10% of the global population. For more than three decades, thiazide diuretics, a common medication used for high blood pressure, have been the standard of care for kidney ...

The sodium–chloride cotransporter (NCC) is a protein dimer central to sodium handling by the kidney and is the target of an important class of drug for high blood pressure called thiazide diuretics.

Effect size: decrease in blood pressure after thiazide treatment. Studies are listed in chronological order and divided into single genes, gene interactions and genome-wide association studies. † ...

Kidney stones affect nearly 10% of the global population. For more than three decades, thiazide diuretics, a common medication used for high blood pressure, have been the standard of care for kidney ...

Death risk doubled for patients experiencing early hyponatremia after starting a thiazide diuretic. Patients who experience hyponatremia soon after starting thiazide diuretics have an increased risk ...

An angiotensin-converting-enzyme (ACE) inhibitor, the most common first-line approach for newly diagnosed hypertension, is not as effective and causes more adverse effects than a thiazide diuretic, a ...

SAN DIEGO--Thiazide, a popular diuretic for lowering high blood pressure, may not excrete salt as expected in patients with congestive heart failure and or dehydration and should be taken with caution ...

“This finding reflects a drug effect over the course of a lifetime, unconstrained by the limited follow-up period of clinical trials.” An analysis of genetic proxies of thiazide diuretics may support ...