Before a cell divides, its DNA is replicated so that each daughter cell inherits the same genetic information. The two copies ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 114, No. 4 (January 24, 2017), pp. 675-680 (6 pages) The eukaryotic genome is primarily replicated by two DNA ...

A new study from Karolinska Institutet, published in Nature Communications, reveals that cyclin-dependent kinases (CDK) ...

In mitosis, DNA replication is initiated through the actions of various multiprotein complexes that recognize the start sites within a chromosome and cause the separation of DNA into two ...

Our lab studies the mechanism of eukaryotic chromosome replication. Chromosomes are the carriers of the genetic and epigenetic information and faithful chromosome replication is of fundamental ...

Many cancers harbor pro-proliferative mutations of the mitogen-activated protein kinase (MAPK) pathway. In BRAF-driven melanoma cells treated with BRAF inhibitors, subpopulations of cells escape ...

The replication of DNA is initiated at particular sites on the genome called replication origins (ROs). Understanding the constraints that regulate the distribution of ROs across different organisms ...

Many common viruses responsible for childhood illnesses establish a home for life within us. This is evidenced in a new study carried out at the University of Helsinki and published in Nucleic Acids ...