One of the most detailed 3D maps of how the human chromosomes are organized and folded within a cell's nucleus is published ...

New 3D genome maps reveal how DNA folding controls gene activity, offering fresh clues into disease and cell function.

In diagrams and illustrations of cells, DNA is sometimes shown as a mass in the cell's nucleus, like a bowl of ramen noodles. For many years, it's been standard practice to take images of cells that ...

Researchers at the CNIO show that oestrogens regulate gene expression by changing DNA supercoiling. Hormone-activated ...

After 10 years, members of the 4D Nucleome consortium have successfully completed the first phase of a project that aims to ...

Although it also performs some functions in men, estrogen, the main female sex hormone, is involved in a myriad of processes, ...

In human cells, there are about 20,000 genes on a two-meter DNA strand—finely coiled up in a nucleus about 10 micrometers in diameter. By comparison, this corresponds to a 40-kilometer thread packed ...

This led researchers to hypothesize that hnRNP E1 might also interact with DNA. Their results, published online on July 16 in the journal Life Science Alliance, describe a novel role for hnRNP E1 in ...

Traits as diverse as the color of a person's eyes and the scent of a rose are determined by the information contained in DNA. Learn how this information is coded by strings of molecules called ...

Estrogens, the main female sex hormone, although they also perform some functions in men, are involved in a myriad of ...

DNA can sustain serious injuries called double strand breaks, in which both strands of the helix snap. These breaks are among ...

In an era where the U.S. healthcare system spends $4.5T annually yet faces systemic failures, with life expectancy plummeting to a three-decade low and chronic disease rates at an all-time high, the ...