People inherit two copies of each gene - one from each parent - an evolutionary fail-safe to ensure survival even when one of them doesn't function. For cancer-suppressor genes like BRCA1, researchers ...

A study led by Harvard Medical School researchers shed new light on how even a single defective copy of the tumor-suppressor BRCA1 gene can increase patients’ risk of developing breast cancer.

Mutations in the BRCA1 gene that are either inherited (germline) or acquired (somatic) might not be key to the initiation of prostate cancer, as previously thought, suggests the first study of its ...

The decision to start or add to your family is always a big one, and when you have a higher risk of cancer because of a BRCA gene mutation, it may feel even bigger. But having a BRCA1 or BRCA2 variant ...

A large international analysis found no adverse effect of menopausal hormonal therapy among women with high genetic cancer risks.