The serotonin 1A receptor (5-HT1A) has a major role in modulating the effects of serotonin on mood and behavior. Previous studies have shown that knockout of 5-HT1A selectively in the raphe leads to ...

Mice were bred in the Department of Comparative Medicine animal facility at the New York State Psychiatric Institute (NYSPI) at the Columbia University Medical Center. The floxed tetO1B mouse model ...

Generations of studying the root cause of schizophrenia have largely converged around a single theory: the “dopamine hypothesis,” which postulates that a combination of genetic susceptibility, ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, No. 17 (Aug. 16, 1994), pp. 8297-8301 (5 pages) The tone and regulation of the brain dopaminergic projections ...

The caudate nucleus (green) is a subcortical brain region located in the striatum. The striatum is one of several neural structures that make up the basal ganglia (colored regions) located below the ...