Smooth muscle cells use an actin-myosin II-based contractile apparatus to produce force for a variety of physiological functions, including blood pressure regulation and gut peristalsis. The ...

This is a preview. Log in through your library . Abstract Although it is generally believed that phosphorylation of the regulatory light chain of myosin is required before smooth muscle can develop ...

Cell generated force plays essential roles in a wide range of biological processes, such as cell motility, cytokinesis, and tissue morphogenesis. In a study published in Nature Communications, a ...

Hypertrophic cardiomyopathy (HCM) is the most common hereditary heart disease. It causes the left ventricle to thicken, the ...

Temperature is a key physiological factor that determines the speed of immune reactions. While this may seem obvious, it has remained largely unexplored at the single-cell level-until now.

Cytokinetics Inc. has disclosed fast skeletal muscle myosin inhibitors reported to be useful for the treatment of Becker muscular dystrophy, Duchenne muscular dystrophy, facioscapulohumeral muscular ...

Building muscle isn’t just a matter of showing up and working out however and whenever you want. Looking in the mirror doesn’t help either (sorry). You have to incorporate a few important strategies ...

The novel cardiac myosin inhibitor aficamten improved peak oxygen uptake in symptomatic obstructive hypertrophic cardiomyopathy (HCM), the pivotal SEQUOIA-HCM trial showed. At 24 weeks, the mean ...