The Giants host the 49ers at MetLife Stadium, with Big Blue — one week after Cam Skattebo’s gruesome injury — trying to keep hope for the year alive.

The New York Giants play host to the San Francisco 49ers on Sunday in a battle of teams missing multiple star players on both sides of the ball.

The San Francisco 49ers, led by quarterback Mac Jones, face the New York Giants, led by quarterback Jaxson Dart, on Sunday, Nov. 2, 2025 at MetLife Stadium in East Rutherford, N.J.

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The Giants were on the short end of a tough whistle in Philadelphia, and after winning the first meeting, the defending Super Bowl champions flipped the script and were the more physical football team on both sides of the ball.

The 49ers just lost 26-15 to the Houston Texans, who came into the game with just two wins and four losses. Now, the 49ers have five wins and three losses, which is good, but they didn't play like a playoff team today. They played like pure pretenders.